GABA (Gamma-Amino Butyric acid)
Gaba (Gamma-Amino Butyric acid) is an amino acid which acts as a neurotransmitter in the central nervous system. It inhibits nerve transmission in the brain, calming nervous activity. As a supplement it is sold and promoted for these neurotransmitter effects as a natural tranquilizer. GABA is gama amino butyric acid, and is an inhibitory neurotransmitter that is essential for the proper function of your brain and the central nervous system, and has the effect of reducing excessive brain activity and promoting a state of calm. In spastic diplegia in humans, GABA absorption becomes impaired by nerves damaged from the condition's upper motor neuron lesion, which leads to hypertonia of the muscles signaled by those nerves that can no longer absorb GABA.
GABA and Depression
GABA is the most potent depressive neuroamine in human brains. It regulates many of the depressive and sedative actions in brain tissue and is critical for relaxation. GABA is a natural calming and anti epileptic agent. It is vital for proper brain functioning. GABA also helps our bodies make endorphins, chemicals that make us feel happy. The theory of Depression and GABA, which is prevalent these days says that lower level plasma of GABA may recognize a tendency that is inheritable for mood swings like that of depression. Today's view is that things which increase GABA in these people may trigger a depressive episode. It is not until time or treatment restores GABA to its former low level that these people feel better
GABA Benefits
Research shows that GABA might play a key role in protecting against depression and anxiety. GABA is manufactured by the body and deficiencies are rare, although depletion of GABA levels can occur due to environmental toxins and other external stressors. People deficient in GABA may experience anxiety, depression, insomnia, and muscle fatigue. Many medical specialists that research GABA believe that if your body does not have the quantity of the substance that it needs to function properly, this is a precursor to stress, sleep deprivation, depression, or anxiety.
• GABA Relieves stress and anxiety.
• GABA Shown to have anti ageing effects.
• GABA Helps lose fat and improve lean muscle.
• Essential for proper brain function.
• GABA Maintain our normal memory functions.
• GABA is the major inhibitory neurotransmitter in the brain.
• GABA increases Human Growth Hormone (HGH).
GABA Receptors
The GABA receptors are a class of receptors that respond to the neurotransmitter GABA (gamma-aminobutyric acid), the chief inhibitory neurotransmitter in the vertebrate central nervous system. A subclass of ionotropic GABA receptors, insensitive to typical allosteric modulators of GABA receptor channels such as benzodiazepines and barbiturates, was designated GABA receptor. However, there are numerous reports of excitatory GABA receptors. This phenomenon is due to increased intracellular concentration of Cl ions either during development of the nervous system. In studies focused on the control of neurotransmitter release, it was noted that a GABA receptor was responsible for modulating evoked release in a variety of isolated tissue preparations. GABA receptors are probably the most common kind in the mammalian nervous system.
GABA Neurotransmitter
GABA is the most abundant neurotransmitters in the central nervous system. Neurons that produce GABA as their output are called GABA ergic neurons, and have chiefly inhibitory action at receptors in the adult vertebrate. Medium Spiny Cells are a typical example of inhibitory CNS GABAergic cells. In contrast, GABA exhibits both excitatory and inhibitory actions in insects, mediating muscle activation at synapses between nerves and muscle cells, and also the stimulation of certain glands. In mammals, some GABAergic neurons, such as chandelier cells, are also able to excite their glutamatergic counterparts. GABA is inhibitory or hyperpolarizing. When the net flow of chloride is close to zero, the action of GABA is shunting. Shunting inhibition has no direct effect on the membrane potential of the cell. That is to say, GABA's role changes from excitatory to inhibitory as the brain develops into adulthood.
GABA Brain development
GABA itself is partially responsible for orchestrating the maturation of ion pumps. GABA ergic interneurons mature faster in the hippocampus and the GABA signalling machinery appears earlier than glutamatergic transmission. Thus, GABA is the major excitatory neurotransmitter in many regions of the brain before the maturation of glutamatergic synapses. Although GABA remains the predominant inhibitory neurotransmitter of the brain, there are numerous recent examples of excitatory actions of GABA. Two metabolites of GABA are present in uniquely high concentrations in the human brain. Homocarnosine and pyrrolidinone have a major impact on GABA metabolism in the human brain.
GABA References
• https://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid.
• Petroff OA (December 2002). "GABA and glutamate in the human brain.
• Schousboe A, Waagepetersen HS, "GABA: homeostatic and pharmacological aspects.
• Bouché N, Fromm H (March 2004). GABA in plants just a metabolite.
• Roberts MR (September 2007). "Does GABA Act as a Signal in Plants.
• Roberts, E. Failure of GABAergic inhibition a key to local and global seizures.
• Roberts, E., Chase, T.N., and Tower, D.B., eds. GABA in Nervous System Function
• Macdonald, R.L., Gallagher, M.J., Feng, Kang, GABAA receptor epilepsy mutations.
• Bowery, N. G.; Enna, S. J. (1997). The GABA receptors.
